Ke hāpai nei kekahi hui ʻAmelika i kahi ala hou no ka hoʻonohonoho ʻana i nā lasers microdisk

Ua ʻōlelo kahi hui noiʻi hui mai ke Kula Lapaʻau ʻo Harvard (HMS) a me ka Halemai Nui ʻo MIT ua hoʻokō lākou i ka hoʻonohonoho ʻana i ka hopena o kahi laser microdisk me ka hoʻohana ʻana i ke ʻano hana PEC etching, e hana ana i kahi kumu hou no nā nanophotonics a me ka biomedicine "hoʻohiki."

(Hiki ke hoʻololi ʻia ka hopena o ka laser microdisk e ke ʻano hana PEC etching)

Ma nā kahua onā nanophotonicsa me ka lāʻau lapaʻau bio, microdisknā lasersa ua lilo nā lasers nanodisk i mea hoʻohikinā kumu kukuia me nā probes. Ma kekahi mau noi e like me ke kamaʻilio photonic ma ka chip, bioimaging ma ka chip, biochemical sensing, a me ka hana ʻike photon quantum, pono lākou e hoʻokō i ka hopena laser i ka hoʻoholo ʻana i ka wavelength a me ka pololei o ka band ultra-narrow. Eia nō naʻe, paʻakikī mau ka hana ʻana i nā lasers microdisk a me nanodisk o kēia wavelength pololei ma kahi pae nui. Hoʻolauna nā kaʻina hana nanofabrication o kēia manawa i ka randomness o ke anawaena disc, kahi e paʻakikī ai ka loaʻa ʻana o kahi wavelength i hoʻonohonoho ʻia i ka hana ʻana a me ka hana ʻana o ka nui laser. I kēia manawa, he hui o nā mea noiʻi mai ke Kula Lapaʻau ʻo Harvard a me ke kikowaena Wellman o ka Halemai Nui o Massachusetts noLāʻau lapaʻau Optoelectronicua hoʻomohala i kahi ʻenehana kālai ʻana optochemical (PEC) hou e kōkua ana i ka hoʻoponopono pololei ʻana i ka nalu laser o kahi laser microdisk me ka pololei o ka subnanometer. Ua paʻi ʻia ka hana ma ka puke pai Advanced Photonics.

Ka ʻoki ʻana i ke kiʻi photochemical
Wahi a nā hōʻike, ʻo ke ʻano hana hou a ka hui e hiki ai ke hana ʻia nā lasers micro-disk a me nā ʻāpana laser nanodisk me nā nalu hoʻokuʻu i hoʻoholo mua ʻia. ʻO ke kī i kēia holomua ʻo ka hoʻohana ʻana i ka PEC etching, kahi e hāʻawi ai i kahi ala kūpono a hiki ke hoʻonui ʻia e hoʻomaikaʻi i ka nalu o kahi laser microdisc. Ma nā hopena i luna, ua loaʻa i ka hui nā microdisks indium Gallium arsenide phosphating i uhi ʻia me ka silica ma ka ʻōnaehana kolamu indium phosphide. A laila ua hoʻonohonoho pono lākou i ka nalu laser o kēia mau microdisks i kahi waiwai i hoʻoholo ʻia ma ka hana ʻana i ka etching photochemical i loko o kahi hopena diluted o ka sulfuric acid.
Ua noiʻi pū lākou i nā ʻano hana a me nā dinamika o nā etchings photochemical kikoʻī (PEC). ʻO ka hope loa, ua hoʻoili lākou i ka pūʻulu microdisk i hoʻonohonoho ʻia i ka wavelength ma luna o kahi substrate polydimethylsiloxane e hana i nā ʻāpana laser kūʻokoʻa, hoʻokaʻawale ʻia me nā wavelengths laser like ʻole. Hōʻike ka microdisk hopena i kahi bandwidth ultra-wideband o ka hoʻokuʻu ʻana o ka laser, me kalaserma ke kolamu emi ma mua o 0.6 nm a me ka ʻāpana i hoʻokaʻawale ʻia emi ma mua o 1.5 nm.

Ke wehe nei i ka puka i nā noi biomedical
ʻO kēia hopena e wehe i ka puka i nā nanophotonics hou a me nā noi biomedical. No ka laʻana, hiki i nā lasers microdisk kū hoʻokahi ke lawelawe ma ke ʻano he barcodes physico-optical no nā laʻana biological heterogeneous, e hiki ai ke lepili i nā ʻano cell kikoʻī a me ka hoʻolālā ʻana o nā molekala kikoʻī i ka nānā ʻana o multiplex. Hana ʻia ka lepili ʻano cell i kēia manawa me ka hoʻohana ʻana i nā biomarkers maʻamau, e like me nā fluorophores organik, nā kiko quantum, a me nā beads fluorescent, nona nā linewidths hoʻokuʻu ākea. No laila, hiki ke lepili ʻia kekahi mau ʻano cell kikoʻī i ka manawa like. I ka hoʻohālikelike ʻana, hiki i ka hoʻokuʻu ʻana o ke kukui band ultra-narrow o kahi laser microdisk ke ʻike i nā ʻano cell hou aʻe i ka manawa like.
Ua hoʻāʻo a hōʻike pono ka hui i nā ʻāpana laser microdisk i hoʻonohonoho pono ʻia e like me nā biomarkers, me ka hoʻohana ʻana iā lākou e lepili i nā cell epithelial umauma maʻamau i hoʻoulu ʻia ʻo MCF10A. Me kā lākou hoʻokuʻu ultra-wideband, hiki i kēia mau lasers ke hoʻololi i ka biosensing, me ka hoʻohana ʻana i nā ʻano hana biomedical a me optical i hōʻoia ʻia e like me ke kiʻi cytodynamic, flow cytometry, a me ka loiloi multi-omics. ʻO ka ʻenehana e pili ana i ka PEC etching e hōʻailona ana i kahi holomua nui i nā lasers microdisk. ʻO ka scalability o ke ʻano, a me kona pololei subnanometer, e wehe i nā mea hou no nā noi helu ʻole o nā lasers i nā nanophotonics a me nā mea biomedical, a me nā barcodes no nā heluna cell kikoʻī a me nā molekala analytical.